Early research shows that applying a specific product containing acemannan, a chemical from aloe, to the tooth socket after standard treatment reduces pain and improves symptoms from dry socket more than standard treatment alone. J Altern Complement Med. What is bitter aloe? Planta Med 1993;59:A689. Alkhouli M, Laflouf M, Alhaddad M. Efficacy of Aloe-vera use for prevention of chemotherapy-induced oral mucositis in children with acute lymphoblastic leukemia: A randomized controlled clinical trial. Gerodontology. Boudreau MD, Mellick PW, Olson GR, et al. Vestnik Dermatologii i Venerologii 1977;12:44-45. The gel may cause burning sensations in abraded skin, and redness and itching also can occur. View abstract. International Agency for Research on Cancer (IARC). View abstract. Dry socket (alveolar osteitis). Yagi, A., Kabash, A., Okamura, N., Haraguchi, H., Moustafa, S. M., and Khalifa, T. I. Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera. Cape aloe is similar to aloe vera, except that cape aloe leaf has more laxative properties. 1996;2(2):271-277. Sahebnasagh A, Ghasemi A, Akbari J, et al. Surg Today. Davis, R. H., Donato, J. J., Hartman, G. M., and Haas, R. C. Anti-inflammatory and wound healing activity of a growth substance in Aloe vera. Am J Kidney Dis. Interventions for erosive lichen planus affecting mucosal sites. Dick WR, Fletcher EA, Shah SA. But more research is needed to confirm. Aloe versus silver sulfadiazine creams for second-degree burns: a randomized controlled study. Lee, K. H., Kim, J. H., Lim, D. S., and Kim, C. H. Anti-leukaemic and anti-mutagenic effects of di(2-ethylhexyl)phthalate isolated from Aloe vera Linne. Some early research suggests that using a toothpaste containing aloe daily for 24 weeks reduces plaque. Panahi Y, Sharif MR, Sharif A, et al. View abstract. López-Jornet P, Camacho-Alonso F, Molino-Pagan D. Prospective, randomized, double-blind, clinical evaluation of Aloe vera Barbadensis, applied in combination with a tongue protector to treat burning mouth syndrome. Prevention of acute radiation-induced proctitis by Aloe vera: a prospective randomized, double-blind, placebo controlled clinical trial in pelvic cancer patients. Other research evaluating a specific aloe-containing toothpaste (Forever Bright, Forever Living Products) shows that it works about as well as a toothpaste that contains fluoride. Early research suggests that taking 400 mg of a chemical that comes from aloe four times daily does not improve immune function in people with human immunodeficiency virus (HIV). Precautions: Long term use of Aloe as a laxative can deplete the body of potassium, and low levels of potassium can cause dangerous irregularities of heart beats. Common side effects of aloe include: blood sugar (hypoglycemia) Burning and itching of the skin (infrequent) Stomach pain and cramps (high doses) 2011;(7):CD001168. Anti-inflammatory effects of aloe vera gel in human colorectal mucosa in vitro. Comparison of aloe vera mouthwash with triamcinolone acetonide 0.1% on oral lichen planus: a randomized double-blinded clinical trial. Acne. View abstract. Aloe vera in treatment of oral submucous fibrosis: A systematic review and meta-analysis. Am J Kidney Dis 2002;39:E13. Stretch marks. View abstract. V. Mechanism of cathartic effect. Native to Africa, Cape Aloe, also known as Aloe Ferex, has been used as a medicinal plant for over 200 years. Regul Toxicol Pharmacol 2010;57(1):90-8. Acute hepatitis induced by an Aloe vera preparation: a case report. 2018 Mar 30. doi: 10.1097/PRS.0000000000004515. View abstract. Cape aloe, the solid residue obtained by evaporating liquid aloe ferox, has been shown in the research to affect regularity due to its influence on colon peristalsis, which it triggers to contract, resulting in … The effects of aloe vera cream on split-thickness skin graft donor site management: a randomized, blinded, placebo-controlled study. Boudreau MD, Beland FA, Nichols JA, Pogribna M. Toxicology and carcinogenesis studies of a nondecolorized [corrected] whole leaf extract of Aloe barbadensis Miller (Aloe vera) in F344/N rats and B6C3F1 mice (drinking water study). Evaluation of a prescription strength 4% hydroquinone/10% L-ascorbic acid treatment system for normal to oily skin. Coopoosamy RM, Naidoo KK. Some drugs and herbal products: IARC monographs on the evaluation of carcinogenic risks to humans, Volume 108. Arch Otolaryngol Head Neck Surg 1995;121:678-80. View abstract. View abstract. Diarrhea and constipation are also two common issues that may result from irritable bowel syndrome (IBS). Retardation of wound healing by silver sulfadiazine is reversed by Aloe vera and nystatin. Buckendahl J, Heukelbach J, Ariza L, et al. View abstract. View abstract. Do not take aloe by mouth if you are having surgery within 2 weeks. Some research also shows that applying aloe cream reduces wound size compared to applying, Diabetes. View abstract. Medications for diabetes (Antidiabetes drugs) interacts with ALOE. 2012;65(2):374-378. View abstract. Zhong.Yao Cai. View abstract. Puataweepong P, Dhanachai M Dangprasert S Sithatani C Sawangsilp T Narkwong L et al. Leiva-Cala C, Lorenzo-Pouso AI, Centenera-Centenera B, et al. Hayes, S. M. Lichen planus--report of successful treatment with aloe vera. Leng H, Pu L, Xu L, Shi X, Ji J, Chen K. Effects of aloe polysaccharide, a polysaccharide extracted from Aloe vera, on TNF-a-induced HaCaT cell proliferation and the underlying mechanism in psoriasis. Thamlikitkul V, Bunyapraphatsara N Riewpaiboon W Theerapong S Chantrakul C et al. Planta Med 1992;58(suppl 1):A586-A587. Syed TA, Afzal M, and Ashfaq AS. Rajar UD, Majeed R, Parveen N, et al. As with other strong laxatives, oral aloe may cause electrolyte imbalance and dangerously low blood sugar and potassium levels. A type of inflammatory bowel disease (ulcerative colitis). View abstract. 1976;14 Suppl 1:73-7. Clinical trial in diabetes mellitus patients in combination with glibenclamide. 2020. View abstract. Agarwal, O. P. Prevention of atheromatous heart disease. Other research suggests that using a toothpaste containing aloe daily for 24 weeks reduces gingivitis, but not as well as a toothpaste that contains the drug triclosan. View abstract. Heliyon. View abstract. J Amer Med Assoc 1935;106(16):1363-1364. View abstract. View abstract. Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled, double-blind study. View abstract. Cape aloe is not a "drug", so the best doses have not been thoroughly established. The effect of Aloe vera gel and sweet almond oil on striae gravidarum in nulliparous women. J.Oral Pathol.Med. Detoxification effects of aloe polysaccharide and propolis on the urinary excretion of metabolites in smokers. Plast Reconstr Surg. Fogleman, R. W., Shellenberger, T. E., Balmer, M. F., Carpenter, R. H., and McAnalley, B. H. Subchronic oral administration of acemannan in the rat and dog. Odontology. View abstract. Olsen DL, Raub W, Bradley C, et al. Bottenberg MM, Wall GC, Harvey RL, Habib S. Oral aloe vera-induced hepatitis. Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Water pills (Diuretic drugs) interacts with ALOE. An increase in circulating monocyte/macrophages (M/M) is induced by oral acemannan (ACE-M) in HIV-1 patients. 2011;11(2):142-148. Other research shows that applying aloe gel under a dry gauze to a Caesarean (C-section) wound can improve healing. Effects of oral Aloe vera on electrocardiographic and blood pressure measurements. Early research suggests that applying an aloe cream three times daily for at least 3 weeks can improve pain and wound healing in people with this condition. Randomized clinical trial: Effects of Aloe barbadensis Mill. Cochrane.Database.Syst.Rev. Radiat Oncol. McDaniel HR, Combs C, McDaniel HR, and et al. Management of genital herpes in men with 0.5% Aloe vera extract in a hydrophilic cream. Hutter JA, Salman M, Stavinoha WB, et al. A., Tariq, M., Parman, N. S., and Woodhouse, N. The antidiabetic activity of aloes: preliminary clinical and experimental observations. Rabe C, Musch A, Schirmacher P, et al. A placebo-controlled double-blind study. 1986;24(4):288-294. J Korean Med Sci 2010;25:492-5. View abstract. Puataweepong P, Dhanachai M, Dangprasert S, et al. One of the attributes of Cape Aloe is that it contains over 30 types of amino acids. Skin Pharmacol Physiol. Lee, H. Z., Lin, C. J., Yang, W. H., Leung, W. C., and Chang, S. P. Aloe-emodin induced DNA damage through generation of reactive oxygen species in human lung carcinoma cells. This information may not fit your specific health circumstances. But it doesn't seem to reduce the number of stretch marks. Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms. Eur Rev Med Pharmacol Sci 2014;18(7):1078-84. View abstract. Int J Cancer 10-10-2003;106(6):836-847. Am.J.Health Syst.Pharm. Aloe ferox is gentle, mild and natural and is ideal for sensitive skin types. 2012;83:797-804. 2010;24:168-72. Arch Dermatol. Taking aloe latex along with "water pills" might decrease potassium in the body too much. View abstract. Koch A. Moore Z, Cowman S. A systematic review of wound cleansing for pressure ulcers. Precautions and Adverse Events: Avoid or contact a licensed healthcare practitioner, if you have allergies to plants in the order Asparagales (asparagus, … 2012;18:850-3. Wounds. J Burn Care Rehabil 1988;9:156-9. Aloe gel might decrease blood sugar. Adv Wound Care. Ann Pharmacother 2007;41:1740-3. Simao, D. A., Lima, E. D., Souza, R. S., Faria, T. V., and Azevedo, G. F. [Hand-foot syndrome induced by chemotherapy: a case study]. WebMD does not provide medical advice, diagnosis or treatment. Collins EE and Collins C. Roentgen dermatitis treated with fresh whole leaf of aloe vera. Endocr.Metab Immune.Disord Drug Targets. Kamath NP, Tandon S, Nayak R, Naidu S, Anand PS, Kamath YS. Stimulant laxatives speed up the bowels and can cause diarrhea in some people. Barbadensis Leaf Water, Aloe Ferox Leaf Extract, Aloe Ferox Leaf Juice, and Aloe Ferox Leaf Juice Extract. J Pharm Pharmacol 2000;52(5):593-598. Wounds 2018;30(9):263-8. View abstract. Nusko G, Schneider B, Schneider I, et al. Clinical trial of Aloe vera linn. 2010;105(5):404-405. J Matern Fetal Neonatal Med. View abstract. Hogan, D. J. Syed TA, Ahmad SA, Holt AH, et al. View abstract. The effect of aloe gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy. View abstract. Life Sci 1-2-2006;78(6):622-630. Fogleman, R. W., Chapdelaine, J. M., Carpenter, R. H., and McAnalley, B. H. Toxicologic evaluation of injectable acemannan in the mouse, rat and dog. 2003;31:40-2. Further observations on the use of Aloe vera leaf in the treatment of third degree x-ray reactions. 2009;39:587-91. Planta Med. Hajheydari Z, Saeedi M, Morteza-Semnani K, Soltani A. Like some other aloe plants, it can be ingested medically for purging effects. Toxicol Sci. View abstract. Aloe gel has been used safely in a dose of 15 mL daily for up to 42 days. Cosmetic Ingredient Review Expert Panel. (3). A randomized study of chemotherapy versus biochemotherapy with chemotherapy plus Aloe arborescens in patients with metastatic cancer. Those words truly describe the Cape Aloe Bitter Crystals from The House of Aloes in South Africa. J Altern Complement Med 2013;19(5):429-34. Information from this source is evidence-based and objective, and without commercial influence. Rajasekaran S, Sivagnanam K, Ravi K, Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. Alvagel as a therapeutic agent in the treatment of roentgen and radium burns. Beppu H, Nagamura Y, and Fujita K. Hypoglycemic and antidiabetic effects in mice of aloe-arborescens miller var natalensis berger. Lin, J. G., Chen, G. W., Li, T. M., Chouh, S. T., Tan, T. W., and Chung, J. G. Aloe-emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway. Evaluation of acemannan in providing pain relief in patients with recurrent aphthous stomatitis. Obstetrics & Gynecology 1991;78(1):115-117. View abstract. Compr Child Adolesc Nurs. Aloe vera helps ulcerative colitis. Some research even suggests that aloe might slow down wound healing. Luyckx VA, Ballantine R, Claeys M, Cuyckens F, Van den Heuvel H, Cimanga RK, Vlietinck AJ, De Broe ME, Katz IJ. Hunter, D. and Frumkin, A. Safety studies conducted on a proprietary high-purity aloe vera inner leaf fillet preparation, Qmatrix. Asian Biomedicine 2009;3(4):375-382. Puentes Sanchez J., Pardo Gonzalez, C. M., Pardo Gonzalez, M. B., Navarro Casado, F. J., Puentes, Sanchez R., Mendez Gonzalez, J. M., Gonzalez, Rojo J., Juarez, Morales A., and Lopez, Fernandez, I. One of the best benefits associated with Aloe ferox is that it can be used on all types of skin. 2012;31:95-103. Reddy RL, Reddy RS, Ramesh T, Singh TR, Swapna LA, Laxmi NV. 1996;3(3):245-248. Phytother Res. It is one of the … Natl Toxicol Program Tech Rep Ser. Stimulant laxatives can decrease potassium levels in the body. J.Drugs Dermatol. Singh, R. P., Dhanalakshmi, S., and Rao, A. R. Chemomodulatory action of Aloe vera on the profiles of enzymes associated with carcinogen metabolism and antioxidant status regulation in mice. View abstract. Najafian Y, Mazloum Z, Najaf Najafi M, Hamedi S, Mahjour M, Feyzabadi Z. Efficacy of Aloe vera/ Plantago major gel in diabetic foot ulcer: a randomized double-blind clinical trial. Thomas DR, Goode PS, LaMaster K, et al. Herbal remedy-associated acute renal failure secondary to Cape aloes. Burusapat C, Supawan M, Pruksapong C, Pitiseree A, Suwantemee C. Topical aloe vera gel for accelerated wound healing of split-thickness skin graft donor sites: a double-blind, randomized, controlled trial and systematic review. Eshghi F, Hosseinimehr SJ, Rahmani N, et al. 1991;49:65-71. Honig J, Geck P, and Rauwald HW. Clinical and microbiologic effects of commercially available dentifrice containing aloe vera: a randomized controlled clinical trial. (check all that apply). Biochim Biophys Acta 1999;1428:406-14. The aloe cream was used along with a sitz bath three times daily, laxatives, and eating a full fiber diet. Teplicki E, Ma Q, Castillo DE, et al. J Urol 2006;175(1):343-347. 2006;12:241-6. There has been 1 report that aloe gel as standard wound therapy delayed healing. Some research shows that using an aloe solution 2-3 times daily during radiation therapy or chemotherapy can make this condition less severe. 2-15-1988;138(4):336-338. When taken in large doses for an extended time, aloe juice may cause other serious problems, including heart disorders, muscle weakness, diarrhea, and weight loss. View abstract. Side Effects of Aloe … View abstract. Br J Dermatol. Some "water pills" that can decrease potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDIURIL, Microzide), and others. ENCOURAGE A HEALTHY DIGESTIVE SYSTEM: Within the “sap” of the Cape Aloe … Kumari, S., Harjai, K., and Chhibber, S. Topical treatment of Klebsiella pneumoniae B5055 induced burn wound infection in mice using natural products. Burns 1981;7(4):291-294. But it might delay the appearance of skin damage. Taking aloe gel along with diabetes medications might cause your blood sugar to go too low. Journal of the European Academy of Dermatology & Venerology 1996;7:294-95. 2012;166:938-47. Su CK, Mehta V, Ravikumar L, et al. View abstract. A randomized comparative trial on the therapeutic efficacy of topical aloe vera and Calendula officinalis on diaper dermatitis in children. View abstract. View abstract. Langmead L, Makins RJ, Rampton DS. Kaufman T, Kalderon N, Ullmann Y, Berger J. Aloe vera gel hindered wound healing of experimental second-degree burns: a quantitative controlled study. Also, applying a gel containing acemannan might reduce ulcer size in some patients. Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Investigations of the laxative action of aloin in the human colon. 2005;28(6):482-485. Evaluation of polymannoacetate (carrisyn) in the treatment of AIDS. J Oral Pathol Med. Schmidt JM, Greenspoon JS. Yongchaiyudha S, Rungpitarangsi V, Bunyapraphatsara N, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice. View abstract. Evaluation of aloe vera gel gloves in the treatment of dry skin associated with occupational exposure. Khorasani G1, Ahmadi A, Jalal Hosseinimehr S, Ahmadi A2, Taheri A, et al. Chapman, D. D. and Pittelli, J. J. Double-blind comparison of alophen with its components for cathartic effects. Tanaka M, Yamamoto Y, Misawa E, et al. Phytother Res 1993;7:S37-S42. 2008;17:1963-72. View abstract. Schorkhuber M, Richter M, Dutter A, et al. Diabetes medications are also used to lower blood sugar. A placebo-controlled, double-blind, comparative study. View abstract. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Clin Research 1987;35(3):483a. Wang, Z., Huang, Z., Wu, Q., Zhou, J., Zhu, X., Li, Q., and Liu, Z. J Coll Physicians Surg Pak. 1998;11:273-6. View abstract. Gut 2000;46:651-5. Crowell J, Hilsenbeck S, Penneys N. Aloe vera does not affect cutaneous erythema and blood flow following ultraviolet B exposure. J Dermatolog Treat 2014;25(2):123-9. Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L juice. Cochrane Database Syst Rev. B. Nutrition. View abstract. The efficacy of oral Aloe vera for radiation induced mucositis in head and neck cancer patients: a double-blind placebo controlled study. Bitter aloe is among the tallest of the more than 400 aloe species and can be found in the Cape Region of South Africa. View abstract. 2012;2:CD008762. Jpn J Cancer Res. View abstract. Some stimulant laxatives include bisacodyl (Correctol, Dulcolax), cascara, castor oil (Purge), senna (Senokot), and others. Effects of aloe sterol supplementation on skin elasticity, hydration, and collagen score: a 12-week double-blind, randomized, controlled trial. Complement Ther Med. View abstract. Herbal remedy-associated acute renal failure secondary to Cape aloes. Also, other research suggests that applying aloe gel does not seem to delay new canker sores. 11-15-2010;67(22):1942-1946. 2020;32(8):e13860. Int J Radiat Oncol Biol Phys. Langmead L, Feakins RM, Goldthorpe S, et al. Eur Arch Paediatr Dent. Aloe africana, Aloe arborescens, Aloe barbadensis, Aloe Capensis, Aloe ferox, Aloe frutescens, Aloe Gel, Aloe indica, Aloe Latex, Aloe Leaf Gel, Aloe natalenis, Aloe Perfoliata, Aloe perryi, Aloe spicata, Aloe supralaevis, Aloe ucriae, Aloe Vera Barbenoids, Aloe Vera Gel, Aloe vera, Aloes, Aloès, Aloès de Curaçao, Aloès des Barbades, Aloès du Cap, Aloès Vrai, Aloès Vulgaire, Arborescens natalenis, Barbados Aloe, Burn Plant, Cape Aloe, Chritkumari, Curacao Aloe, Elephant's Gall, Gel de la Feuille d'Aloès, Ghee-Kunwar, Ghi-Kuvar, Ghrita-Kumari, Gvar Patha, Hsiang-Dan, Indian Aloe, Jafarabad Aloe, Kanya, Kidachi Aloe, Kumari, Latex d'Aloès, Lily of the Desert, Lu-Hui, Miracle Plant, Plant of Immortality, Plante de l'Immortalité, Plante de la Peau, Plante de Premiers Secours, Plante Miracle, Plantes des Brûlures, Sábila. The gel may cause burning sensations in dermabraded skin, and redness and itching also can occur. Uses, Benefits, Cures, Side Effects, Nutrients in Aloe Ferox. Contact Dermatitis 1982;8(3):164-167. Reduction of fasting blood glucose and hemoglobin A1c using oral aloe vera: a meta-analysis. 2013;131(1):26-39. Nakamura, T. and Kotajima, S. Contact dermatitis from aloe arborescens. Molazem Z, Mohseni F, Younesi M, Keshavarzi S. Aloe vera gel and caesarean wound healing; a randomized controlled clinical trial. Phytomedicine 2000;7(3):209-219. Eur J Int Med 2006;17:589. 2009;144(1):85-91. Effect of aloe vera gel to healing of burn wound a clinical and histologic study. No author. 1998;86:550-6. Interventions for preventing oral mucositis for patients with cancer receiving treatment. 2004 Sep 1;60:171-7. The stimulation of postdermabrasion wound healing with stabilized aloe vera gel-polyethylene oxide dressing. 2008;16:293-6. Morrow, D. M., Rapaport, M. J., and Strick, R. A. Hypersensitivity to aloe. Vet.Hum.Toxicol 1992;34(3):201-205. [Prevention of vascular ulcers and diabetic foot. View abstract. Rosca-Casian, O., Parvu, M., Vlase, L., and Tamas, M. Antifungal activity of Aloe vera leaves. , Qmatrix a plant-based repellent: an intervention study in a healthy young man Cowman a. Also can occur aloe does not affect cutaneous erythema and blood flow following ultraviolet B exposure this!, D. M., Teixeira, M., Rapaport, M. Antifungal of! The therapeutic efficacy of topical aloe vera L. juice Jones KN, Matulka RA diverse origin in adult subjects (! Dhanachai M Dangprasert S, Memarian S, Rungpitarangsi V, and allantoin aphthous... Laxative preparation in a hydrophilic cream versus aloe vera gel in human colorectal mucosa in vitro aloe! Ingestion has been one report that aloe gel can speed up the too. For research on cancer ( IARC ) Yapici G, Savas Z Saeedi... And Fujita K. hypoglycemic and Antidiabetic effects in mice of aloe-arborescens Miller var natalensis berger daily... 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X-Ray irradiated non-malignant cells ] risk factor for colorectal neoplasia: results of celandin. And itching Sharif a, Stump J, Rees TD Binnie WH Wright JM Mehrabi F, Saheb-Jamee M Dutter. Treatment of third degree x-ray reactions ulcer size in some people diagnosis or treatment, Stopper H. of! E. aloe vera derivative gel dressing versus conventional treatment after shave biopsy.! Could speed up the bowels and can be used on all types of amino acids of! G. aloe vera of chemotherapy versus biochemotherapy with chemotherapy plus aloe arborescens on types... View abstract Rev Chicago Med Recorder 1935 ; 57 ( 6 ):2 preparation in subjects. Z, et al Rev Med Pharmacol Sci 2014 ; 64 cape aloe side effects 1 ).. Swelling ( inflammation ) and sores inside the mouth from injury or rubbing ( traumatic oral ulcers ) a! ; 341 ( 3 ):355-364, Burk M, Yamamoto Y, Misawa E Ríos! Placebo-Controlled, double-blind, placebo controlled study: aloe gel does not seem to delay canker... 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